Mipu1 overexpression protects macrophages from oxLDL-induced foam cell formation and cell apoptosis

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成果类型：

期刊论文

作者：

Qu, Shun-Lin;Fan, Wen-Jing;Zhang, Chi;Guo, Fang;Han, Dan;...

通讯作者：

Jiang, Zhi-Sheng

作者机构：

[Jiang, Zhi-Sheng; Qu, Shun-Lin; Guo, Fang; Li, Wei; Zhang, Chi; Han, Dan; Feng, Da-Ming; Pan, Wen-Jun; Fan, Wen-Jing] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Postdoctoral Mobile Stat Basic Med, Hengyang City 421001, Hunan, Peoples R China.

[Fan, Wen-Jing] Univ South China, Affiliated Hosp 2, Hengyang City 421001, Hunan, Peoples R China.

[Jiang, Zhi-Sheng] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

通讯机构：

[Jiang, Zhi-Sheng] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 West Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Oxidative stress;Quantitative polymerase chain reaction

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2014

卷：

期：

页码：

839-846

DOI：

10.1089/dna.2014.2501

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100212, 81170277, 81100106]; Ph.D. Programs Foundation of Ministry of Education of ChinaMinistry of Education, China [20114324120004, 20124324110003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M511383]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [11C1094, 11C1095]; Science and Technology Project of Hunan Province [2014FJ3014]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; Construct Program of the Key Discipline in Human Province [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Mipu1 (myocardial ischemic preconditioning upregulated protein 1) is a novel N-terminal Kruppel-associated box (KRAB)/C2H2 zinc finger superfamily protein, that displays a powerful effect in protecting H9c2 cells from oxidative stress-induced cell apoptosis. The present study aims to investigate the effect of Mipu1 overexpression on oxidized low-density lipoprotein (oxLDL)-induced foam cell formation, cell apoptosis, and its possible mechanisms. New Zealand healthy rabbits were used to establish atherosclerosis model, and serum levels of trigly...

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Mipu1 overexpression protects macrophages from oxLDL-induced foam cell formation and cell apoptosis

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