Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Meng, Chao;Cao, Yufei;Sun, Lu;Liu, Yuping;Kang, Guiying;...

通讯作者：

Wei, Hua

作者机构：

[Wei, Hua; Meng, Chao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Thrget New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Meng, Chao] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Liu, Yuping; Wei, Hua; Peng, Jinlei; Ma, Wei; Deng, Kaicheng; Ma, Liwei; Sun, Lu; Meng, Chao; Cao, Yufei; Kang, Guiying] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

通讯机构：

[Wei, Hua] U

[Wei, Hua] L

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Thrget New Dr, Hengyang 421001, Peoples R China.

Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

语种：

英文

期刊：

BIOMATERIALS SCIENCE

ISSN：

2047-4830

年：

2020

卷：

期：

页码：

4206-4215

DOI：

10.1039/d0bm00656d

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072, 21504035]; Thousand Young Talent Program; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry; Chinese Academy of SciencesChinese Academy of Sciences

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Fabrication of cyclic graft (cg) copolymer-based polymeric prodrugs by conjugation of drug molecules to cg copolymers via a dynamic covalent bond capable of responding to biorelevant signals integrates simultaneously the merits of cg copolymers and polymeric prodrugs for enhanced stability of nanocarriers and precise modulation of drug release kinetics. To completely eliminate the compromised drug conjugation efficiency due to the steric hindrance of hydrophilic grafts, it will be useful to develop cg polymeric prodrugs with heterogeneous graft...

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Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release

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