Erratum for Luo et al., “Integrative metabolomics highlights gut microbiota metabolitesas novel NAFLD-related candidate biomarkers in children”

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成果类型：

期刊论文

作者：

Luo, Jiayou;Luo, Miyang;Kaminga, Atipatsa C.;Wei, Jia;Dai, Wen;...

通讯作者：

Pan, XF

作者机构：

[Pan, Xiongfeng; Luo, Jiayou; Yao, Zhenzhen; Luo, Miyang; Dai, Wen; Xiao, Xiang; Wei, Jia; Duan, Yamei; Ouyang, Sisi; Liu, Yixu] Cent South Univ, Xiangya Sch Publ Hlth, Dept Maternal & Child Hlth, Changsha, Peoples R China.

[Pan, Xiongfeng; Kaminga, Atipatsa C.] Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Pediat Res Inst Hunan Prov,Xiangya Sch Med, Changsha, Peoples R China.

[Kaminga, Atipatsa C.] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China.

[Kaminga, Atipatsa C.] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.

[Kaminga, Atipatsa C.] Mzuzu Univ, Dept Math & Stat, Mzuzu, Malawi.

通讯机构：

[Pan, XF ] C

Cent South Univ, Xiangya Sch Publ Hlth, Dept Maternal & Child Hlth, Changsha, Peoples R China.

Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Pediat Res Inst Hunan Prov,Xiangya Sch Med, Changsha, Peoples R China.

语种：

英文

关键词：

alanine aminotransferase;aromatic compound;aspartate aminotransferase;biological marker;creatinine;flavonoid;gallic acid;icosanoid;interleukin 12;interleukin 17;interleukin 1beta;interleukin 21;interleukin 32;interleukin 6;interleukin 8;lauric acid;RNA 16S;taurine;triacylglycerol;tumor necrosis factor;biological marker;creatinine;alcohol consumption;Alistipes;anthropometry;Article;biochemical analysis;child;cohort analysis;controlled study;electrospray;fatty acid metabolism;feces analysis;female;flow rate;human;human cell;intestine flora;KEGG;lipid metabolism;liquid chromatography-mass spectrometry;liver cell;liver function;major clinical study;male;metabolite;metabolomics;multiple reaction monitoring;nonalcoholic fatty liver;nonalcoholic steatohepatitis;obesity;precipitation;prospective study;quality control;retention time;reversed phase liquid chromatography;RNA sequencing;tandem mass spectrometry;THLE-3 cell line;ultra performance liquid chromatography;childhood obesity;inflammation;liver;metabolism;metabolomics;pathology;Biomarkers;Child;Creatinine;Gastrointestinal Microbiome;Humans;Inflammation;Liver;Metabolomics;Non-alcoholic Fatty Liver Disease;Pediatric Obesity

期刊：

MICROBIOLOGY SPECTRUM

ISSN：

2165-0497

年：

2024

卷：

期：

页码：

e0101724

DOI：

10.1128/spectrum.05230-22

基金类别：

MOST | National Natural Science Foundation of China (NSFC) This work was supported by the National Natural Science Foundation of China (81872641) and the Natural Science Foundation of Hunan Province (2021JJ30901 and 2022JJ40668). We also 649 sincerely thank the distinguished editors and reviewers for their constructive 650 comments that improved the clarity of this article.

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Altered gut microbiota and metabolites are important for non-alcoholic fatty liver disease (NAFLD) in children. We aimed to comprehensively examine the effects of gut metabolites on NAFLD progression. We performed integrative metabolomics (untargeted discovery and targeted validation) analysis of non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), and obesity in children. Fecal samples were collected from 75 subjects in the discovery cohort (25 NAFL, 25 NASH, and 25 obese control children) and 145 subjects in an independent ...

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Erratum for Luo et al., “Integrative metabolomics highlights gut microbiota metabolitesas novel NAFLD-related candidate biomarkers in children”

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