期刊论文

Wang, Z

英文

European Journal of Medicinal Chemistry

0223-5234

2022

228

113985

10.1016/j.ejmech.2021.113985

This study was technically supported by Lanzhou University , Ministry of Education of China , and was financially supported by the Recruitment Program of Global Experts (1000 Talents Plan). Qinghai Key Laboratory of Tibetan Medicine Research(2021-ZJ-Y03); Science and Technology Program of Qinghai Province (No. 2018-ZJ-745); CAS “Light of West China” Program A (2017). We thank the Scientific Research and Experiment Center of School of Pharmacy of Lanzhou University for support in instrumentation, and the mass spectrometry facility at the School of Life Sciences of Lanzhou University for support in proteomics data acquisition.

本校为其他机构

This article describes the syntheses and biological activity of five 3-arylisoquinoline natural products corydamine (1), N-formyl Corydamine (2), hypecumine (3), Decumbenine B (XW) and 2-(1,3-dioxolo [4,5-h]isoquinolin-7-yl)-4,5-dimethoxy-N-methyl-Benzeneethanamine (A), and twelve analogues. Among them, 1, 2, and A were synthesized for the first time. In vitro screening for anti-proliferative activity showed that derivative 1a could significantly inhibit the proliferation of HCC cells (IC50 = 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells), a...