Aims: Apelin is the endogenous ligand for the G protein coupled receptor APJ.It promotes vascular smooth muscle cell proliferation and monocyte adhesion to endothelial cells.In our previous research,we found that apelin-13 promotes H9c2 rat cardiomyocytes hypertrophy by PI3K-Akt-ERK1/2-p70S6K and PI3K-autophagy pathway.The objective of this study was to explore the role of apelin-13 on the regulation of ER stress and autophagy,And then to investigate the association of ER stress and autophagy with the improvement of cell diameter,cell volum...
