Design, synthesis, and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and suppress cell migration

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成果类型：

期刊论文

作者：

Liu, Yun-Mei*;Li, Yang;Xiao, Jie;Zhang, Qi-Zhi;Song, Jian-Xin*

通讯作者：

Liu, Yun-Mei;Song, Jian-Xin

作者机构：

[Liu, Yun-Mei; Song, Jian-Xin] Hunan Normal Univ, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Minist Educ China, Key Lab Chem Biol & Tradit Chinese Med, Changsha 410081, Hunan, Peoples R China.

[Xiao, Jie; Liu, Yun-Mei; Li, Yang; Zhang, Qi-Zhi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Liu, Yun-Mei] Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

[Song, Jian-Xin] Hunan Normal Univ, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Liu, Yun-Mei] U

[Song, Jian-Xin] H

Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

Hunan Normal Univ, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Changsha 410081, Hunan, Peoples R China.

语种：

英文

关键词：

Chrysin derivatives;amino acid;anticancer;apoptotic

期刊：

亚洲天然物产研究(英文版)

ISSN：

1028-6020

年：

2020

卷：

期：

页码：

547-561

DOI：

10.1080/10286020.2019.1597056

基金类别：

Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ2349]; University of South China Students Research Learning and Innovative Experimental Project [2018147200]

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Amino acid derivatives containing chrysin were synthesized for evaluating their anticancer effects. Among them, compound N-(7-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)heptanoyl)-L-isoleucine (6e) displayed the most potent antiproliferative activity against MGC-803 cells with IC50 value of 20.0M. Preliminary mechanistic studies showed that compound 6e could inhibit the colony formation and migration of MGC-803 cells. Flow cytometry analysis demonstrated that compound 6e mediated cell apoptosis of MGC-803 cells and arrested cell cycle in G2/M-phase. Moreover, 6e treatment in MGC-803 cells ...

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Design, synthesis, and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and suppress cell migration

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