Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hong, Tao;Wen, Jie;Mei, Lang;Li, Ruixiang;Zhou, Junlin;...

通讯作者：

Xiao, XH

作者机构：

[Hong, Tao; Mei, Lang; Xiao, Xin-Hua; Li, Jiaoyang; Wen, Jie; Li, Ruixiang] Univ South China, Affiliated Hosp 2, Med Coll, Dept Endocrinol & Metab, Hengyang, Peoples R China.

[Zhou, Junlin] Univ South China, Affiliated Hosp 1, Med Coll, Hlth Management Ctr, Hengyang, Peoples R China.

[Xiao, Xin-Hua; Xiao, XH] Univ South China, Med Coll, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, XH ] U

Univ South China, Med Coll, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

autophagy;insulin, diabetes;forkhead box protein O1;gamma-aminobutyric acid A receptor-associated protein-like 1;hepatocellular carcinoma;type 2 diabetes

期刊：

HORMONE AND METABOLIC RESEARCH

ISSN：

0018-5043

年：

2023

卷：

期：

页码：

634-641

DOI：

10.1055/a-2119-3301

基金类别：

Natural Science Foundation of Hunan Province — http://dx.doi. org/10.13039/501100004735; No. 2020JJ4544; National Natural Science Foundation of China — http://dx.doi.org/10.13039/ 501100001809; No. 81870595; Health Commission of Hunan Province — http://dx.doi.org/10.13039/100017695; No. A2017011

机构署名：

本校为第一且通讯机构

摘要：

Hyperinsulinemia and insulin resistance in T2D have a potent suppressive effect on hepatic autophagy, however, the underlying mechanisms remain unclear. To explore the effect of insulin on hepatic autophagy and its possible signaling pathways, HL-7702 cells were treated with insulin with or without insulin signaling inhibitors. The interaction between insulin and the promoter region of GABARAPL1 was assessed through luciferase assay and EMSA. There were significant dose-dependent decreases in the number of intracellular autophagosomes and the protein levels of GABARAPL1 and beclin1 in i...

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Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1

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