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Intelligent polymeric micelles for multidrug co-delivery and cancer therapy

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成果类型:
期刊论文
作者:
Yu, Guangping;Ning, Qian;Mo, Zhengcheng;Tang, Shengsong*
通讯作者:
Tang, Shengsong
作者机构:
[Tang, Shengsong; Yu, Guangping] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Henyang 421001, Peoples R China.
[Tang, Shengsong; Yu, Guangping; Ning, Qian] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua, Peoples R China.
[Mo, Zhengcheng] Univ South China, Hengyang Med Sch, Dept Histol & Embryol, Clin Anat & Reprod Med Applicat Inst, Henyang, Peoples R China.
通讯机构:
[Tang, Shengsong] U
Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Henyang 421001, Peoples R China.
语种:
英文
关键词:
Polymeric micelles;cancer therapy;drugs release;multidrug co-delivery;tumour targeting;uptake
期刊:
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN:
2169-1401
年:
2019
卷:
47
期:
1
页码:
1476-1487
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30270684]; Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Science and Technology Plan Key Projects of Hunan Province [10A087]; Hunan Provincial University Innovation Platform Open Fund Project [09K072, 12K120, 15K111]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50416]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment. However, the development of intelligent PMs further allows PMs to accurately -target tumour, selectively release cargo multidrug and increase uptake. Therefore, targets, controlled release and uptake of intelligent PMs should be paid more attention to improvement synergistic therapeutic outcomes and minimize side effects. In this review, tumour targeting of co-delivery intelligent PMs and its intracellular trafficking mechanisms were overviewed. And this review provides a comprehensive summarization of se...

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