A single mitochondria-targetable fluorescent probe for visualizing cysteine and glutathione in ferroptosis of myocardial ischemia/reperfusion injury

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成果类型：

期刊论文

作者：

Zeng, Jiayu;Liu, Minhui;Yang, Ting;Li, Songjiao;Cheng, Dan*;...

通讯作者：

Cheng, Dan;He, LW

作者机构：

[Liu, Minhui; He, LW; Zeng, Jiayu; He, Longwei; Yang, Ting; Cheng, Dan; Li, Songjiao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Peoples R China.

[Zeng, Jiayu; He, Longwei] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch, Hengyang 421002, Peoples R China.

通讯机构：

[He, LW ; Cheng, D] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Peoples R China.

语种：

英文

关键词：

Cysteine;Ferroptosis;Fluorescent probe;Glutathione;Mitochondria;Myocardial ischemia/reperfusion injury

期刊：

Talanta

ISSN：

0039-9140

年：

2024

卷：

270

页码：

125610

DOI：

10.1016/j.talanta.2023.125610

基金类别：

CRediT authorship contribution statement Jiayu Zeng: Conceptualization, Data curation, Formal analysis, Validation, Writing - original draft, Writing - review & editing. Minhui Liu: Data curation, Methodology. Ting Yang: Data curation, Investigation, Validation. Songjiao Li: Methodology, Validation. Dan Cheng: acquisition, Supervision, Writing - review & editing. Longwei He: Conceptualization, acquisition, Project administration, Supervision, Writing - original draft, Writing - review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Ferroptosis plays an important role in the early stage of myocardial ischemia/reperfusion (MI/R) injury, which is closely associated with the antioxidant damage of mitochondrial cysteine (Cys)/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis. Visualization of Cys and GSH in mitochondria is meaningful to value ferroptosis and further contributes to understanding and preventing MI/R injury. Herein a mitochondria-targetable thiols fluorescent probe (MTTP) was designed and synthesized based on sulfonyl benzoxadiazole (SBD) chromophore with a triphenylphosphine unit as the mitochondria-target...

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A single mitochondria-targetable fluorescent probe for visualizing cysteine and glutathione in ferroptosis of myocardial ischemia/reperfusion injury

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