Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

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成果类型：

期刊论文

作者：

Dong, Jun;Chen, Li;Ye, Fei;Tang, Junhui;Liu, Bing;...

通讯作者：

Song, Zhiyin;He, H

作者机构：

[Wu, Min; Song, Zhiyin; He, H; Chen, Li; He, He; Liu, Bing; Meng, Qingtao; Ye, Fei; Dong, Jun; Lin, Jiacheng; Tang, Junhui; Zhou, Pang-Hu] Wuhan Univ, Renmin Hosp, Coll Life Sci,Dept Anesthesiol, TaiKang Ctr Life & Med Sci,Frontier Sci Ctr Immun, Wuhan, Hubei, Peoples R China.

[Song, Zhiyin; He, H; Chen, Li; He, He] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Hubei, Peoples R China.

[Song, Zhiyin; He, H; Chen, Li; He, He] Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infe, Wuhan, Hubei, Peoples R China.

[Lu, Bin] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

[Lu, Jia-Hong] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China.

通讯机构：

[Song, ZY; He, H ] W

Wuhan Univ, Renmin Hosp, Coll Life Sci,Dept Anesthesiol, TaiKang Ctr Life & Med Sci,Frontier Sci Ctr Immun, Wuhan, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infe, Wuhan, Hubei, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2024

卷：

期：

页码：

168

DOI：

10.1038/s41467-023-44057-6

基金类别：

National Natural Science Foundation of China (National Science Foundation of China) [2018YFA0800700]; Ministry of Science and Technology of the People's Republic of China [32125011, 31970711, 91854107]; National Natural Science Foundation of China [2042022dx0003]; Fundamental Research Funds for the Central Universities

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. Here, we show that Mic19, a key subunit of MICOS (mitochondrial contact site and cristae organizing system) complex, regulates ER-mitochondria contacts by the EMC2-SLC25A46-Mic19 axis. Mic19 liver specific knockout (LKO) leads to the reduction of ER-mitochondrial contacts, mitochondrial lipid metabolism disorder, disorganization of mitochondrial ...

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Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

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