High-density lipoprotein in cardiovascular diseases: From high quantity to high quality

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成果类型：

期刊论文

作者：

Zhang, Yifang;Yu, Mengyao;Chen, Yan;Huang, Ji*

通讯作者：

Huang, Ji

作者机构：

[Yu, Mengyao; Zhang, Yifang] Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China

[Chen, Yan] Department of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, China

[Huang, Ji] Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China. Electronic address: huangjicpu@hotmail.com

通讯机构：

[Huang, Ji] D

Department of Pathophysiology, Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China. Electronic address:

语种：

英文

关键词：

Cholesterol efflux capacity;HDL functionality;HDL paradox;HDL subclasses (HDL2, HDL3);HDL-particle (HDL-P);High-density lipoprotein

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2026

卷：

578

页码：

120574

DOI：

10.1016/j.cca.2025.120574

基金类别：

CRediT authorship contribution statement Yifang Zhang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Mengyao Yu: Writing – review & editing, Resources. Yan Chen: Writing – review & editing, Resources. Ji Huang: Writing – original draft, Supervision, acquisition, Conceptualization. Acknowledgements Not applicable. Ethics approval and consent to participate Not applicable. This study was supported by the National Natural Science Foundation of China (82100789), the Natural Science Foundation of Hunan Province (2022JJ40378). This study was supported by the National Natural Science Foundation of China (82100789), the Natural Science Foundation of Hunan Province (2022JJ40378).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

High-density lipoprotein (HDL) plays a key role in reverse cholesterol transport (RCT), traditionally associated with cardiovascular protection. However, while low HDL-cholesterol (HDL-C) levels correlate with increased cardiovascular risk, therapeutic interventions raising HDL-C (e.g., niacin, fibrates) have failed to reduce cardiovascular events. Recent evidence reveals a U-shaped relationship between HDL-C and mortality, with both excessively high and low levels conferring risk—indicating functional impairment as the critical determinant. C...

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High-density lipoprotein in cardiovascular diseases: From high quantity to high quality

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