High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPAR gamma/CD36 Pathway in Inflammatory Adipocytes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhong, Qiaoqing;Zhao, Shuiping;Yu, Bilian;Wang, Xing;Matyal, Robina;...

通讯作者：

Jiang, Zhisheng

作者机构：

[Jiang, Zhisheng; Zhong, Qiaoqing] Univ South China, Postdoctoral Mobile Stn Basic Med, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhisheng; Zhong, Qiaoqing] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Qiaoqing] First Peoples Hosp Chenzhou, Dept Cardiol, Chenzhou 423000, Peoples R China.

[Yu, Bilian; Zhong, Qiaoqing; Zhao, Shuiping] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China.

[Wang, Xing] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China.

通讯机构：

[Jiang, Zhisheng] U

Univ South China, Postdoctoral Mobile Stn Basic Med, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Lipoprotein;Atherosclerosis;Inflammation;Lipopolysaccharide

期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ISSN：

1449-2288

年：

2015

卷：

期：

页码：

256-265

DOI：

10.7150/ijbs.10258

基金类别：

Arteriosclerology Hunan Science and Technology Innovation Team; Research Fund of Hunan Provincial Department of Public Health [B2010-013]; Research Fund of the Chenzhou Scientific and Technological Administration; Research Found of First People's Hospital of Chenzhou City [N2012-001]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Aim: Previous studies have demonstrated that the dysregulated-secretion of adipokines by adipocytes may contribute to obesity-associated atherosclerosis (As) and high density lipoprotein (HDL) may protect against atherogenesis through multiple pathways. This study was to explore the effect of HDL on the oxLDL uptake in inflammatory adipocytes stimulated by endotoxin lipopolysaccharide (LPS) and the possible mechanism. Methods and Results: 3T3-L1 adipocytes were cultured and induced to differentiation and maturation. Acute inflammation in adipoc...

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High-density Lipoprotein Increases the Uptake of Oxidized Low Density Lipoprotein via PPAR gamma/CD36 Pathway in Inflammatory Adipocytes

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