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Interactions between mycoplasma lipid-associated membrane proteins and the host cells

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成果类型:
期刊论文
作者:
Xiao-xing You;Yan-hua Zeng;Yi-mou Wu
通讯作者:
You, X.X.
作者机构:
[Xiao-xing You; Yan-hua Zeng; Yi-mou Wu] Institute of Pathogenic Biology, School of Medicine, Nanhua University, Hengyang, China
语种:
英文
关键词:
Mycoplasma;Lipid-associated membrane proteins (LAMPs);Toll-like receptor (TLR);Immunomodulin
关键词(中文):
支原体;宿主细胞;原核生物
期刊:
浙江大学学报(英文版)B辑:生物医学与生物技术
ISSN:
1673-1581
年:
2006
卷:
7
期:
5
页码:
342-350
基金类别:
Project (No. 30570093) supported by the National Natural Science Foundation of China.ACKN0WLEDGEMENT The authors wish to thank WAN Yan-ping and WANG Xin for their critical review of the manuscript, and thank Yi Chao-qun and WANG Ji-ping for their assistance with its preparation.
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also c...
摘要(中文):
Mycoplamas 是广泛地在自然散布的一组无墙的初核质,其中一些为人是病原的;动物。有许多脂蛋白在血浆膜的外部脸上抛锚了,叫的联系类脂化合物的膜蛋白质(灯) 。灯是高度反遗传因子;能经历阶段;尺寸变化,;被天生的免疫系统通过像使用费的受体(TLR ) 认出 2;6。灯能调制免疫系统,;能导致有免疫力的房间 apoptosis 或死亡。另外,他们可以与宿主细胞的恶意的转变联系;也被认为是在爱滋病的前进的余因子。

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