Kinetics model of DNA double-strand break repair in eukaryotes

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成果类型：

期刊论文

作者：

Shen, Wangtao;Ma, Yun*;Qi, Huizhou;Wang, Wuzhou;He, Junyan;...

通讯作者：

Ma, Yun;He, Shuya

作者机构：

[Wang, Wuzhou; He, Shuya; Shen, Wangtao; Qi, Huizhou; Ma, Yun] Univ South China, Inst Biochem & Mol Biol, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Qi, Huizhou] Univ South China, Hengyang Med Coll, Funct Lab Ctr, Hengyang 421001, Peoples R China.

[Wang, Wuzhou; He, Shuya; Qi, Huizhou; Xiao, Fangzhu] Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.

[Zhu, Hui] Univ South China, Inst Engn Math, Math & Phys Coll, Hengyang 421001, Peoples R China.

[He, Junyan] Univ South China, Affiliated Hosp 1, Dept Radiat Oncol, Hengyang 421001, Peoples R China.

通讯机构：

[Ma, Yun] I

[He, Shuya] H

Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China. Electronic address:

Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China. Electronic address:

语种：

英文

关键词：

DNA double-strand break;DSB reaction intermediate;Kinetics of DSB repair;Mathematical model

期刊：

DNA Repair

ISSN：

1568-7864

年：

2021

卷：

100

页码：

103035

DOI：

10.1016/j.dnarep.2020.103035

基金类别：

National Natural Science Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81741143, 11705085]; Research Foundation of Education Bureau of Hunan Province, China [17A186]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2018JJ3458, 2020JJ6050]

机构署名：

本校为第一机构

院系归属：

数理学院

药学与生物科学学院

摘要：

This manuscript outlines the kinetics of two main repair pathways of DNA double-strand break (DSB) in eukaryotes: non-homologous end joining (NHEJ) and homologous recombination repair (HRR). In this review, we discuss the precise study of recruitment kinetics of repair proteins based on the latest technologies in the past two decades. Then we simulate the theoretical description of the DNA repair process by mathematical models. In our study, the consecutive reactions chain (CRC) model and continuous-time random walk (CTRW) model have been unified by us, so that we can obtain the function of th...

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Kinetics model of DNA double-strand break repair in eukaryotes

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