Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells

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成果类型：

期刊论文

作者：

Zeng, Si-yu;Luo, Jing-fei;Quan, Hai-yan;Xiao, Yun-bin;Liu, Yu-huan;...

通讯作者：

Qin, Xu-ping

作者机构：

[Zeng, Si-yu; Lu, Hui-qin] Guangdong Second Prov Gen Hosp, Inst Drug Clin Trial, Guangzhou 510317, Guangdong, Peoples R China.

[Luo, Jing-fei; Qin, Xu-ping; Quan, Hai-yan; Liu, Yu-huan] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Luo, Jing-fei; Qin, Xu-ping; Quan, Hai-yan; Liu, Yu-huan] Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Yun-bin] Univ South China, Acad Pediat, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Qin, Xu-ping] H

[Qin, Xu-ping] U

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Lab Vasc Biol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

BioMed Research International

ISSN：

2314-6133

年：

2018

卷：

2018

页码：

1547452

DOI：

10.1155/2018/1547452

基金类别：

This work was supported by National Natural Science Foundation of China (Grant numbers 81173060, 8150041); the Natural Science Foundation of Guangdong Province (Grant number 2015A030310076); the Science and Technology Planning Project of Guangdong Province (Grant number 2016A020226005); the Hunan Provincial Education Department Document (Grant number 2014-405); the Medical Scientific Research Foundation of Guangdong Province (Grant number A2014159); and the Science Foundation of Guangdong Second Provincial General Hospital (Grant number YZ2015-008).

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Objectives. Protein arginine methyltransferase 2 (PRMT2) protects against vascular injury-induced intimal hyperplasia; however, little is known about the role of PRMT2 in angiotensin II (Ang II)-induced VSMCs proliferation and inflammation. This research aims to determine whether PRMT2 inhibits Ang II-induced proliferation and inflammation of vascular smooth muscle cells (VSMCs). Materials and Methods. PRMT2 overexpression was used to elucidate the role of PRMT2 in Ang II-induced VSMCs proliferation and inflammation. Western blotting and revers...

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Protein Arginine Methyltransferase 2 Inhibits Angiotensin II-Induced Proliferation and Inflammation in Vascular Smooth Muscle Cells

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