CpG adjuvant enhances the mucosal immunogenicity and efficacy of a Treponema pallidum DNA vaccine in rabbits

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成果类型：

期刊论文

作者：

Zhao, Feijun;Liu, Shuangquan;Zhang, Xiaohong;Yu, Jian;Zeng, Tiebing;...

通讯作者：

Wu, Yimou

作者机构：

[Wu, Yimou; Zhao, Feijun; Zeng, Tiebing] Univ South China, Pathogen Biol Inst, Hengyang City, Hunan, Peoples R China.

Centers Dis Control Hunan Prov, Changsha, Hunan, Peoples R China.

[Liu, Shuangquan] Cent S Univ, Dept Anat & Neurobiol, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Liu, Shuangquan; Cao, Xunyu] Univ South China, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China.

[Zhang, Xiaohong] Univ South China, Dept Histol & Embryol, Sch Med, Hengyang, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Pathogen Biol Inst, Hengyang City, Hunan, Peoples R China.

语种：

英文

关键词：

DNA vaccine;CpG ODN;membrane protein;Treponema pallidum;Tp Gpd;mucosal adjuvant;mucosal immune

期刊：

Human Vaccines & Immunotherapeutics

ISSN：

2164-5515

年：

2013

卷：

期：

页码：

753-760

DOI：

10.4161/hv.23064

基金类别：

National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [30800996]; projects of Science and Technology Department of Hunan Province [2011TT2014, 2012TT2006]; Provincial Joint Funding of Nature and Science in Hunan Province [11JJ0923]; Natural Science Foundation in Hunan ProvinceNatural Science Foundation of Hunan Province [11JJ4076]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Objectives: The protective response against Treponema pallidum (Tp) infection of a DNA vaccine enhanced by an adjuvant CpG ODN was investigated. Results: The mucosal adjuvant CpG ODN enhanced the production of higher levels of anti-TpGpd antibodies induced by pcD/Gpd-IL-2 in rabbits. It also resulted in higher levels of secretion of IL-2 and IFN-α, and facilitated T cell proliferation and differentiation (p < 0.05). No significant difference about testing index above-mentioned was found in the intranasal immunization group of pcD/Gpd-IL-2 vacc...

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CpG adjuvant enhances the mucosal immunogenicity and efficacy of a Treponema pallidum DNA vaccine in rabbits

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