Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway

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成果类型：

期刊论文

作者：

Chen, Jiao-Jiao;Tao, Jun;Zhang, Xiao-Lei;Xia, Lin-Zhen;Zeng, Jun-Fa;...

通讯作者：

Lv, Yun-Cheng;Li, Guo-Hua;Wang, Zuo

作者机构：

[Zeng, Jun-Fa; Li, Guo-Hua; Tao, Jun; Wei, Dang-Heng; Chen, Jiao-Jiao; Xia, Lin-Zhen; Zhang, Hai; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hengyang Med Co, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hengyang, Hunan, Peoples R China.

[Zhang, Xiao-Lei] Jiangsu Coll Nursing, Huaian, Jiangsu, Peoples R China.

[Lv, Yun-Cheng] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang City 421001, Hunan, Peoples R China.

[Li, GH; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Heng Yang Med Sch, Hengyang City 421001, Peoples R China.

通讯机构：

[Lv, Yun-Cheng; Li, GH; Wang, Z] U

Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang City 421001, Hunan, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Heng Yang Med Sch, Hengyang City 421001, Peoples R China.

语种：

英文

关键词：

Tet methylcytosine dioxygenase 2;atherosclerosis;fibroblast growth factor 21;human umbilical vein endothelial cells;pyroptosis;reactive oxygen species;ubiquinol cytochrome c reductase core protein I

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2020

卷：

期：

页码：

661-670

DOI：

10.1089/dna.2019.5151

基金类别：

This study was supported by the Natural Science Foundation of China (No. 81970389, No. 81070221, No. 81600342, and No. 81770460) and the Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province and the Construct Program of the Key Discipline in Hunan Province (No. 15C1201), the Aid Program (2017KJ268), the Construction Program of Innovation Platform (2017KJ182) from the Science and Technology Bureau of Hengyang City, the third level of Chuanshan Talent project of University of South China (2017CST20), the scientific research foundation for the Excellent Youth of the education department of Hunan province (18B264), and the Innovation project of Huai’an Municipal Science and Technology Bureau (HAB201844).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Fibroblast growth factor 21 (FGF21) is a hormone-like member of the FGF family that is associated with cell death in atherosclerosis. However, its underlying mechanisms remain unclear. In this study, the effect of FGF21 on endothelial cell pyroptosis and its potential mechanisms were investigated. Results showed that FGF21 inhibits oxidized low-density lipoprotein (ox-LDL)-induced pyroptosis and related molecular expression in human umbilical vein endothelial cells (HUVECs). Mitochondrial function was damaged by ox-LDL and restored by FGF21. A ...

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Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway

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