期刊论文

Expressions of TRF1 in human gastric cancer

中文

中国现代医药杂志

1672-9463

2008

10

10

16-18

10.3969/j.issn.1672-9463.2008.10.006

本校为第一机构

目的 研究端粒重复序列结合因子1(TRF1)蛋白在胃癌中的表达及其与胃癌发生发展的关系.方法 用Western blot方法检测TRF1蛋白在10例正常胃黏膜、15例胃癌前病变、20例胃癌、5例淋巴结转移胃癌组织中的表达.结果 TRF1蛋白在癌前病变组、胃癌组、转移癌组比正常组表达高;胃癌组、转移癌组比癌前病变组表达高(P

Objective To explore the relationship between expressions of TRFI protein during human multistage carcinogenesis of gastric cancer. Methods Expression of TRF1 protein was measured by Western blot ing to 10 normal gastric mueosa, 15 precancerous lesions, 20 gastric cancer and 5 lymph nodes with gastric cancer metastasis. Results The expression of TRF1 in gastric cancer tissues was significantly higher than that in normal gastric mucosa and precancerous lesions （P〈0.01）. Low differentiated gastrie cancer had elevated TRF1 expression （P〈0.01）...