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Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two-hybrid assays

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成果类型:
期刊论文
作者:
Sun, Zhenjie;Sun, Yuhui;Li, Yumeng;Luan, Xiuli;Chen, Hui;...
通讯作者:
Lu, Chunxue
作者机构:
[Sun, Yuhui; Lu, Chunxue; Li, Yumeng; Chen, Hui; Luan, Xiuli; Sun, Zhenjie; Wu, Haiying] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
[Peng, Bo] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Lu, Chunxue] U
Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Chlamydia trachomatis;glycogen synthase;yeast two-hybrid assay
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2020
卷:
21
期:
3
页码:
1572-1580
基金类别:
Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471969, 81202374, 31600150]; construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Chlamydia trachomatis (C. trachomatis) is the leading cause of bacterial sexually transmitted diseases and infectious diseases that cause blindness. The pathophysiology of chlamydial infections is poorly understood, but secreted proteins have emerged as key virulence factors. C. trachomatis glycogen synthase (GlgA) is a chlamydial secretory protein, which localizes in the lumen of chlamydial inclusion bodies and the cytosol of host cells. In order to improve understanding of the roles of GlgA in chlamydial pathogenesis, four proteins that inter...

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