Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two–hybrid assays

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成果类型：

期刊论文

作者：

Sun, Zhenjie;Sun, Yuhui;Li, Yumeng;Luan, Xiuli;Chen, Hui;...

通讯作者：

Lu, Chunxue

作者机构：

[Sun, Yuhui; Lu, Chunxue; Li, Yumeng; Chen, Hui; Luan, Xiuli; Sun, Zhenjie; Wu, Haiying] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Peng, Bo] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lu, Chunxue] U

Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

actin capping protein;apolipoprotein A1;bacterial enzyme;CXXC finger protein 1;gelsolin like actin capping protein;glycogen synthase;prohibitin;secretory protein;unclassified drug;virulence factor;bacterial protein;carrier protein;glycogen synthase;protein binding;Article;bacterial cell;cell inclusion;Chlamydia trachomatis;chlamydiasis;HeLa cell line;human;human cell;nonhuman;protein analysis;protein function;protein protein interaction;recombinant plasmid;two hybrid system;Western blotting;Chlamydia trachomatis;enzymology;genetics;host pathogen interaction;metabolism;microbiology;plasmid;procedures;protein analysis;reproducibility;two hybrid system;Bacterial Proteins;Carrier Proteins;Chlamydia Infections;Chlamydia trachomatis;Glycogen Synthase;HeLa Cells;Host-Pathogen Interactions;Humans;Plasmids;Protein Binding;Protein Interaction Mapping;Reproducibility of Results;Two-Hybrid System Techniques

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2020

卷：

期：

页码：

1572-1580

DOI：

10.3892/mmr.2020.10947

基金类别：

This project was supported by the Natural Science Foundation of China (grant nos. 81471969, 81202374 and 31600150), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant no. 2014–5), and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant no. 2015-351). This project was supported by the natural Science Foundation of China (grant nos. 81471969, 81202374 and 31600150), the construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and control Foundation (grant no. 2014‑5), and Hunan Province Cooperative Innovation center for Molecular Target new drug Study (grant no. 2015-351).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Chlamydia trachomatis (C. trachomatis) is the leading cause of bacterial sexually transmitted diseases and infectious diseases that cause blindness. The pathophysiology of chlamydial infections is poorly understood, but secreted proteins have emerged as key virulence factors. C. trachomatis glycogen synthase (GlgA) is a chlamydial secretory protein, which localizes in the lumen of chlamydial inclusion bodies and the cytosol of host cells. In order to improve understanding of the roles of GlgA in chlamydial pathogenesis, four proteins that inter...

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Identification of HeLa cell proteins that interact with Chlamydia trachomatis glycogen synthase using yeast two–hybrid assays

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