Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice

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成果类型：

期刊论文

作者：

Li, Jie;Xie, Zhi-Zhong;Tang, Yong-Bo;Zhou, Jia-Guo;Guan, Yong-Yuan*

通讯作者：

Guan, Yong-Yuan

作者机构：

[Li, Jie; Tang, Yong-Bo; Guan, Yong-Yuan; Zhou, Jia-Guo] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, Guangzhou 510089, Guangdong, Peoples R China.

[Li, Jie; Tang, Yong-Bo; Guan, Yong-Yuan; Zhou, Jia-Guo] Sun Yat Sen Univ, Zhongshan Sch Med, Vasc Res Ctr, Guangzhou 510089, Guangdong, Peoples R China.

[Li, Jie] Sun Yat Sen Univ, Affiliated Hosp 2, Dept Anesthesiol, Guangzhou 510120, Peoples R China.

[Xie, Zhi-Zhong] Univ S China, Coll Sci & Technol, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Guan, Yong-Yuan] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, 74 Zhongshan 2 Rd, Guangzhou 510089, Guangdong, Peoples R China.

通讯机构：

[Guan, Yong-Yuan] S

Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, 74 Zhongshan 2 Rd, Guangzhou 510089, Guangdong, Peoples R China.

语种：

英文

关键词：

ApoE knockout mice;Atherosclerosis;Ginsenoside-Rd;Macrophage;Receptor-operated;Store-operated;Voltage-independent Ca2+ channels

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2011

卷：

652

期：

1-3

页码：

104-110

DOI：

10.1016/j.ejphar.2010.11.017

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30730105, 30973536, 30900530]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2009CB521903]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Recently, it was revealed that the dysfunction of transmembrane Ca 2+ transport, results in an increase in intracellular Ca 2+[Ca2+]i, which is involved in the process of atherosclerosis. We previously demonstrated that ginsenoside-Rd, a purified component from panax notoginseng, is a voltage-independent Ca2+ channels blocker. In this study, we investigated the effects of ginsenoside-Rd on atherosclerosis and the underlying mechanisms in apolipoprotein E deficient (apoE-/-) mice and RAW264.7 cells. Atherosclerotic plaques were stained by Red oi...

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Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice

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