With the rapid development of nuclear energy industry, the bio-toxicities of actinides have drawn more and more attention with respect to their potential harmful effects on ecological environment and bio-organisms. Studying the interaction mechanisms of actinide cations with biomolecules, especially peptides or proteins, can provide useful information in molecular level for understanding the transportation, absorption and deposition pathways of actinides in vivo. Uranium, as a central actinide in nuclear fuel cycle, deserves more research endeavors. In this work, recent progresses about the in...