期刊论文

Chen, Linxi

英文

Clinica Chimica Acta

0009-8981

2015

451

Pt B

191-198

10.1016/j.cca.2015.09.029

This work was supported by the grants from the National Natural Science Foundation of China ( 81470434 and 81270420 ), China Postdoctoral Science Foundation (No. 2014M560647 ), Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department document (Approval number: 2014-405 )), Construct Program of the Key Discipline in Hunan province, Hunan Provincial Natural Science Foundation of China ( 14JJ3102 ), project funded by China Postdoctoral Science Foundation ( 2015T80875 ), Hunan Provincial Science and Technology Project ( 2015RS4040 ), Administration of Traditional Chinese Medicine of Hunan Province ( 201578 ) and Health and Family planning commission of Hunan Province ( B2015-48 ).

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The regulatory peptide apelin is the endogenous ligand for the orphan G protein-coupled receptor APJ. Apelin and APJ exist in a variety of tissues, with special status in the heart, lung and tumors. Consequently, the apelin/APJ system exerts a broad range of activities that affect multiple organ systems. Accumulating evidence indicates that the expressions of apelin and APJ are significantly augmented by hypoxia through the hypoxia-inducible factor-1 alpha (HIF-1α) signaling pathway. Increased apelin promotes cellular proliferation, migration ...