ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Ruoxi;Tan, Jieqiong;Chen, Tingting;Han, Hailong;Tian, Runyi;...

通讯作者：

Zhang, Zhuohua

作者机构：

[Tian, Runyi; Lv, Lu; Wu, Yiming; Zhang, Zhuohua; Chen, Tingting; Tan, Ya; Cui, Jingyi; Shang, Shuai; Wang, Ruoxi; Han, Hailong; Chen, Fang; Tan, Jieqiong; Li, Jie; Guan, Xinjie] Cent S Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha, Hunan, Peoples R China.

[Lu, Jiahong] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China.

[Zhang, Zhuohua] Univ South China, Sch Med, Dept Neurosci, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zhang, Zhuohua] C

[Zhang, Zhuohua] U

Cent S Univ, Xiangya Hosp, Inst Mol Precis Med, Changsha, Hunan, Peoples R China.

Cent S Univ, Ctr Med Genet, Changsha, Hunan, Peoples R China.

Univ South China, Sch Med, Dept Neurosci, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

histone deacetylase 6;autophagosomes

期刊：

JOURNAL OF CELL BIOLOGY

ISSN：

0021-9525

年：

2019

卷：

218

期：

页码：

267-284

DOI：

10.1083/jcb.201804165

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (31330031, 31730036, 81861138012, 81429002, and 81161120498), the Discipline Innovative Engineering Plan of China (111 Program), a key laboratory grant from Hunan Province (2016TP1006), and a grant from the National Key Plan for Scientific Research and Development of China (2016YFC1306000). The authors declare no competing financial interests.

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Mutations in ATP13A2 cause Kufor-Rakeb syndrome, an autosomal recessive form of juvenile-onset atypical Parkinson's disease (PD). Recent work tied ATP13A2 to autophagy and other cellular features of neurodegeneration, but how ATP13A2 governs numerous cellular functions in PD pathogenesis is not understood. In this study, the ATP13A2-deficient mouse developed into aging-dependent phenotypes resembling those of autophagy impairment. ATP13A2 deficiency impaired autophagosome-lysosome fusion in cultured cells and in in vitro reconstitution assays. In ATP13A2-deficient cells or Drosophila melanogas...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问