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Synthesis of enzyme-responsive theranostic amphiphilic conjugated bottlebrush copolymers for enhanced anticancer drug delivery

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成果类型:
期刊论文
作者:
Liu, Fangjun;Wang, Dun;Zhang, Miao;Ma, Liwei;Yu, Cui-Yun;...
通讯作者:
Ma, Liwei(malw@lzu.edu.cn)
作者机构:
[Zhang, Miao; Wei, Hua; Ma, Liwei; Liu, Fangjun] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
[Zhang, Miao; Wei, Hua; Ma, Liwei; Liu, Fangjun] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.
[Wei, Hua; Wang, Dun; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
[Wei, Hua; Wang, Dun; Yu, Cui-Yun] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构:
[Liwei Ma; Hua Wei] S
[Cui-Yun Yu] H
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China<&wdkj&>State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China
语种:
英文
关键词:
Anticancer drug delivery;Cell imaging;Conjugated bottlebrush copolymers;Enzyme-responsive;Theranostic micelles
期刊:
Acta Biomaterialia
ISSN:
1742-7061
年:
2022
卷:
144
页码:
15-31
基金类别:
The authors acknowledge the financial support from the National Natural Science Foundation of China (51473072 and 21504035), the Thousand Young Talent Program, the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences.
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Synthesis of polyfluorene (PF) based theranostic amphiphilic copolymers with simultaneously high drug loading efficiency and tumor microenvironment-specific responsiveness for promoted intracellular drug release and enhanced cancer therapy has been rarely reported likely due to the lack of efficient synthetic approaches to integrate these desirable properties. In this work, we recorded the successful preparation of well-defined theranostic amphiliphilic bottlebrush copolymers composing of fluorescent backbone of PF and tunable enzyme-degradable...

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