Aesculin protects against DSS-Induced colitis though activating PPARγ and inhibiting NF-кB pathway

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成果类型：

期刊论文

作者：

Tiana, Xinlei;Peng, Zhonglu;Luo, Shangpeng;Zhang, Shaolong;Li, Baohui;...

通讯作者：

Zhou, Changlin;Fan, Hongye

作者机构：

[Tiana, Xinlei; Zhang, Shaolong; Li, Baohui; Zhou, Changlin; Fan, Hongye] China Pharmaceut Univ, Sch Life Sci & Technol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.

[Peng, Zhonglu] Xiangnan Univ, Key Lab Univ Hunan Prov Cardiovasc & Cerebrovasc, Dept Pharmacol, Chenzhou 423000, Peoples R China.

[Luo, Shangpeng] Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China.

[Zhou, Changlin; Fan, Hongye] China Pharmaceut Univ, Sch Life Sci & Technol, State Key Lab Nat Med, 639 Longmian Rd, Nanjing 211198, Jiangsu, Peoples R China.

通讯机构：

[Zhou, CL; Fan, HY] C

China Pharmaceut Univ, Sch Life Sci & Technol, State Key Lab Nat Med, 639 Longmian Rd, Nanjing 211198, Jiangsu, Peoples R China.

语种：

英文

关键词：

Aesculin;Macrophage;NF-kappaB;PPAR-gamma;Ulcerative colitis

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2019

卷：

857

页码：

172453

DOI：

10.1016/j.ejphar.2019.172453

基金类别：

This work was supported by the Key Project of Scientific Research Fund of Hunan Provincial Education Department ( 15A177 ), the Technology Research and Development Projects of Chenzhou City ( jsyf2017010 ), the Characteristic Subjects of Pharmacical Application in Hunan Province , the “Double First-Class” University project ( CPU2018GF/GY16 ).

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摘要：

Aesculin, a natural product from the traditional and widely-used Chinese medicine named Cortex fraxini, has attracted attention as a novel therapeutic modulator of inflammation. However, little is known about its effect on ulcerative colitis (UC). This study aimed to investigate the protective effects and mechanisms of aesculin on colitis. The results showed that, few cytotoxicity of aesculin were shown in vivo and in the RAW264.7 macrophages, while aesculin significantly relieved the symptoms of DSS-induced colitis and restrained the expression of inflammatory factors including iNOS, IL-1 bet...

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Aesculin protects against DSS-Induced colitis though activating PPARγ and inhibiting NF-кB pathway

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