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Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

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成果类型:
期刊论文
作者:
Zhang, Wan;Tian, Tian;Gong, Shao-Xin;Huang, Wen-Qian;Zhou, Qin-Yi;...
通讯作者:
Wang, Ai-Ping;Tian, Ying
作者机构:
[Wang, Ai-Ping; Huang, Wen-Qian; Tian, Ying; Zhou, Qin-Yi; Zhang, Wan] Univ South China, Inst Clin Res, Affiliated Nanhua Hosp, Hengyang, Hunan, Peoples R China.
[Tian, Tian] First Hosp Changsha, Dept Clin Lab, Changsha, Hunan, Peoples R China.
[Gong, Shao-Xin] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang, Hunan, Peoples R China.
通讯机构:
[Wang, AP; Tian, Y] U
Univ South China, Inst Clin Res, Affiliated Nanhua Hosp, Hengyang, Hunan, Peoples R China.
语种:
英文
关键词:
antioxidant;CD16 antigen;CD32 antigen;chemokine;cytokine;fibrinogen;fibronectin;gamma interferon;glucocorticoid;glutathione;interleukin 1 receptor blocking agent;interleukin 12;interleukin 13;interleukin 1beta;interleukin 23;interleukin 4;interleukin 6;lipopolysaccharide;matrix metalloproteinase;microRNA;nitric oxide;reactive oxygen metabolite;scavenger receptor;STAT protein;transforming growth factor beta;triggering receptor expressed on myeloid cells 1;tumor necrosis factor;adipose derived stem cell;blood brain barrier;blood clot lysis;brain electrophysiology;brain injury;brain ischemia;cell infiltration;cell phagocytosis;cell proliferation;cell regeneration;cell therapy;down regulation;excitotoxicity;exosome;extracellular matrix;fibrinolytic therapy;gene expression;gene overexpression;human;immunocompetent cell;leukocyte;macrophage;microenvironment;microglia;nervous system development;nervous system inflammation;neuroprotection;nonhuman;occlusive cerebrovascular disease;oxidative stress;pathophysiology;phagocyte;phenotype;Review;signal transduction;thrombectomy;tissue regeneration
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2021
卷:
16
期:
1
页码:
6-11
基金类别:
This work was supported by the National Natural Science Foundation of China, Nos. 31871169
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, there is no effective strategy for treating ischemic stroke in clinical practice. Therefore, it is clinically important to study the role and regulation of microglia in stroke. In this review, we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,...

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