Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons

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成果类型：

期刊论文

作者：

Lv, Yun-Cheng;Gao, An-Bo;Yang, Jing;Zhong, Li-Yuan;Jia, Bo;...

通讯作者：

Peng, Tian-Hong;Sun, Sha;Cayabyab, Francisco S.

作者机构：

[Lv, Yun-Cheng; Zhong, Li-Yuan; Gao, An-Bo; Jia, Bo; Sun, Sha; Ouyang, Shu-Hui; Peng, Tian-Hong; Peng, TH] Univ South China, Hengyang Med Coll, Clin Anat & Reprod Med Applicat Inst, Hengyang, Hunan, Peoples R China.

[Lv, Yun-Cheng; Gui, Le; Cayabyab, Francisco S.] Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK, Canada.

[Gao, An-Bo] Univ South China, Sch Pharmaceut Sci, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Yang, Jing] Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Dept Metab & Endocrinol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Peng, TH; Sun, S; Cayabyab, Francisco S.] U

Univ South China, Hengyang Med Coll, Clin Anat & Reprod Med Applicat Inst, Hengyang, Hunan, Peoples R China.

Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK, Canada.

语种：

英文

关键词：

JNK/c-JUN pathway;cognitive dysfunction;dopaminergic neuron;dyskinesia;long-term adenosine A1 receptor activation;neural regeneration;neurodegenerative diseases;sortilin;alpha-synuclein

期刊：

中国神经再生研究：英文版

ISSN：

1673-5374

年：

2020

卷：

期：

页码：

712-723

DOI：

10.4103/1673-5374.266916

基金类别：

This study was supported by the National Natural Sciences Foundation of China,No.81770460(to YCL) the Postdoctoral Research Fellowship of the Saskatchewan Health Research Foundation,No.SHRF,4144(to YCL) the third level of the Chuanshan Talent project of the University of South China,No.2017CST20(to YCL) the Aid Program,No.2017KJ268 and the Key Lab for Clinical Anatomy&Reproductive Medicine,No.2017KJ182 from the Science and Technology Bureau of Hengyang City,China(to YCL and XC) the Postgraduate Student Research Innovation Projects of Hunan Province,China,No.CX2018B62(to ABG).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases. However, the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear. In this study, rats were intraperitoneally injected with 5 mg/kg of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) for five weeks. The mobility of rats was evaluated by forced swimming test, while their cognitive capabilities were evaluated by Y-maze test. Expression of sortilin, alpha-synuclein, p-JUN, and ...

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Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons

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