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Ferritin,heavy polypeptide 1 interacts with fragile X-related protein 1

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成果类型:
期刊论文
作者:
Ma, Yun;He, Shuya*;Yang, Yang;Chen, Qiong;Xiao, Weichun;...
通讯作者:
He, Shuya
作者机构:
[He, Shuya; Li, Binyuan; Fu, Xianghui; Ma, Yun; Xiao, Weichun] S China Univ, Dept Biol & Biochem, Hengyang 421001, Hunan, Peoples R China.
[Yang, Yang] Zhuzhou 331 Hosp, Dept Clin Lab, Zhuzhou 412002, Hunan, Peoples R China.
[Chen, Qiong] Cent S Univ, Xiangya Hosp, Dept Resp Med, Dept Geriatr Med, Changsha 410008, Hunan, Peoples R China.
[Su, Jiao] Changzhi Med Coll, Dept Biol & Biochem, Changzhi 046000, Hunan, Peoples R China.
通讯机构:
[He, Shuya] S
S China Univ, Dept Biol & Biochem, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
fragile X-related protein;ferritin;heavy polypeptide 1;yeast two-hybrid system;interaction
关键词(中文):
脆性X综合征;相互作用;相关蛋白;铁蛋白;多肽;酵母双杂交系统;哺乳动物细胞;cDNA文库
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2011
卷:
6
期:
10
页码:
790-796
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30370795]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Fragile X-related protein 1(FXR1P) is a member of the FXR gene family,which also includes fragile X mental retardation protein and fragile X-related protein 2(FXR2P).To understand the functions of FXR1P,we screened FXR1P-interacting proteins using a yeast two-hybrid system.FXR1P was fused to pGBKT7 and used as the bait to screen a human fetal brain cDNA library.This screening revealed 10 FXR1P-interacting proteins including FTH1.FTH1 encodes Homo sapiens ferritin,heavy polypeptide 1.The interaction between FXR1P and FTH1 was confirmed by re...

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