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Cytoplasmic M‑CSF facilitates apoptosis resistance by inhibiting the HIF‑1α/BNIP3/Bax signalling pathway in MCF‑7 cells

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成果类型:
期刊论文
作者:
Zhang, Mengxia;Liu, Qi;Li, Lijun;Ning, Jing;Tu, Jian;...
通讯作者:
Tang, SS
作者机构:
[Zhang, Mengxia] Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha 410208, Hunan, Peoples R China.
[Tang, SS; Tang, Shengsong] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.
[Zhang, Mengxia; Liu, Qi; Mo, Zhongcheng] Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.
[Tang, Shengsong; Lei, Xiaoyong; Tu, Jian; Li, Lijun] Univ South China, Insitute Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
[Ning, Jing; Tang, Shengsong] Hunan Univ Med, Dept Pharmacol, Huaihua 418000, Hunan, Peoples R China.
通讯机构:
[Tang, SS ] H
Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.
语种:
英文
关键词:
caspase 3;caspase 9;colony stimulating factor 1;doxorubicin;hoe 33342;hypoxia inducible factor 1alpha;protein Bax;protein BNip3;antineoplastic antibiotic;BAX protein, human;BCL2 protein, human;BNIP3 protein, human;colony stimulating factor 1;CSF1 protein, human;doxorubicin;HIF1A protein, human;hypoxia inducible factor 1alpha;membrane protein;oncoprotein;protein Bax;protein bcl 2;antiapoptotic activity;apoptosis;Article;binding affinity;controlled study;down regulation;flow cytometry;human;human cell;immunoprecipitation;MCF-7 cell line;priority journal;protein expression;protein protein interaction;signal transduction;upregulation;Western blotting;apoptosis;breast tumor;drug effect;drug resistance;female;MCF-7 cell line;metabolism;multidrug resistance;pathology;signal transduction;Antibiotics, Antineoplastic;Apoptosis;bcl-2-Associated X Protein;Breast Neoplasms;Doxorubicin;Drug Resistance, Multiple;Drug Resistance, Neoplasm;Female;Humans;Hypoxia-Inducible Factor 1, alpha Subunit;Macrophage Colony-Stimulating Factor;MCF-7 Cells;Membrane Proteins;Proto-Oncogene Proteins;Proto-Oncogene Proteins c-bcl-2;Signal Transduction
期刊:
ONCOLOGY REPORTS
ISSN:
1021-335X
年:
2019
卷:
41
期:
3
页码:
1807-1816
基金类别:
The present study was supported by the Hunan Provincial Science and Technology Plan Key Projects of China (2017SK2183), the Science and Technology Plan Key Projects of Hunan Province (10A087) and the Hunan Provincial Natural Science Key Foundation of Hunan (09JJ3060).
机构署名:
本校为其他机构
院系归属:
医学院
药学与生物科学学院
摘要:
Macrophage colony-stimulating factor (M-CSF), a tumour marker, is related to tumour cell anti-apoptosis and drug resistance. However, the role of M-CSF in MCF-7 cells is unknown. In the present study, the effect and mechanism of M-CSF on hypoxia-inducible factor-1α (HIF-1α)/BCL2/adeno-virus E1B 19 kDa-interacting protein 3 (BNIP3)/Apoptosis Regulator BAX signalling in human breast cancer MCF-7 cells were investigated. Western blotting revealed that the expression of HIF-1α, BNIP3, Bax, caspase-3 and caspase-9 was lower in MCF-7-M cells compa...

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