This work was supported by the Youth Program of National Natural Science Foundation of China (No. 81500169), the Hunan Province Key Laboratory of Tumour Cellular amp; Molecular Pathology (2016TP1015), and the Key Project of Hunan Provincial Health Commiss [81500169]; Youth Program of National Natural Science Foundation of China [2016TP1015]; Hunan Province Key Laboratory of Tumour Cellular amp; Molecular Pathology [20201921]; Key Project of Hunan Provincial Health Commission
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Background: Myeloid differentiation factor-88 (MyD88) is a crucial adapter protein that coordinates the innate immune response and establishes an adaptive immune response. The interaction of the Toll/Interleukin-1 receptor (IL-1R) superfamily with MyD88 triggers the activation of various signalling pathways such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), promoting the production of a variety of immune and inflammatory mediators and potentially driving the development of a variety of diseases. Objective: This article will exp...
