Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Peng, Yuan;Liu, Yongcheng;Hu, Yabin;Chang, Fangfang;Wu, Qian;...

通讯作者：

Li, Y.-P.;Qu, X.

作者机构：

[Luo, Tingrong; Wei, Youchuan; Peng, Yuan] Guangxi Univ, Coll Anim Sci & Vet Med, Nanning, Guangxi, Peoples R China.

[Zhang, Jian; Wu, Qian; Qu, Xiaowang; Teng, Shishan; Peng, Yuan; He, Rongzhang; Hu, Yabin; Liu, Wenpei] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Hengyang Med Sch, Chenzhou, Peoples R China.

[Chang, Fangfang; Wu, Qian; Liu, Yongcheng; Li, Yi-Ping] Sun Yat sen Univ, Inst Human Virol, Zhongshan Sch Med, Dept Pathogen Biol & Biosecur, Guangzhou, Peoples R China.

[Chang, Fangfang; Wu, Qian; Liu, Yongcheng; Li, Yi-Ping] Sun Yat sen Univ, Zhongshan Sch Med, Key Lab Trop Dis Control, Minist Educ, Guangzhou, Peoples R China.

[Yang, Jing] Southern Med Univ, Sch Lab Med & Biotechnol, Guangzhou, Peoples R China.

通讯机构：

[Qu, X.] T

[Li, Y.-P.] I

Institute of Human Virology, China

Translational Medicine Institute, China

语种：

英文

关键词：

convalescents;coronavirus;COVID-19;middle eastern respiratory syndrome coronavirus;monoclonal antibody;spike protein

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2022

卷：

页码：

1056272

DOI：

10.3389/fimmu.2022.1056272

基金类别：

This work was supported by the SC1-PHE-CORONAVIRUS-2020: Advancing Knowledge for the Clinical and Public Health Response to the 2019-nCoV Epidemic’ from the European Commission (CORONADX, no. 101003562, to Y-PL), National Natural Science Foundation of China (82061138020, 32270996, 82102365), The Science and Technology Innovation Program of Hunan Province of China (2022RC3079), Natural Science Foundation of Hunan Province of China (2021JJ40006, 2022JJ30095), Educational Commission of Hunan Province of China (21A0529), Clinical Medical Innovation Technology Guide Project of Hunan Province (2021SK50304, 2021SK50306 and 2021SK50312). Acknowledgments

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Introduction: The Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly contagious coronaviruses causing MERS and COVID-19, respectively, without an effective antiviral drug and a long-lasting vaccine. Approaches for diagnosis, therapeutics, prevention, etc., particularly for SARS-CoV-2 that is continually spreading and evolving, are urgently needed. Our previous study discovered that >60% of sera from convalescent COVID-19 individuals, but

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Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses

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