Ureaplasma urealyticum GrpE protein elicits glycolysis-mediated inflammatory responses through TLR2 in macrophages

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成果类型：

期刊论文

作者：

Xie, Jing;Xie, Nan;Liu, Chang;Huang, Zhemin;Du, Min;...

通讯作者：

Peng, JF;Li, RH

作者机构：

[Xie, Jing; Hu, Hao; Du, Min; Huang, Zhemin] Hunan Normal Univ, Affiliated Hengyang Hosp, Dept Obstet, Hengyang 421001, Hunan, Peoples R China.

[Xie, Jing; Hu, Hao; Du, Min; Peng, Jiaofeng; Zheng, Kang; Huang, Zhemin] Hengyang Cent Hosp, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Kang; Xie, Nan; Li, Ranhui; Liu, Chang] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang, Peoples R China.

[Peng, Jiaofeng; Zheng, Kang] Hunan Normal Univ, Affiliated Hengyang Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Peng, JF ] H

[Li, RH ] U

Hengyang Cent Hosp, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang, Peoples R China.

Hunan Normal Univ, Affiliated Hengyang Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Ureaplasma urealyticum;GrpE;Glycolysis;Inflammatory response;TLR2

期刊：

Immunobiology

ISSN：

0171-2985

年：

2025

卷：

230

期：

页码：

152902

DOI：

10.1016/j.imbio.2025.152902

基金类别：

Natural Science Foundation Hunan Province, China [2024JJ9581, 2023JJ30523, 2025JJ80602]; Scientific Research Project of Hunan Provincial Health Committee [W20243032]; Scientific Research Project of Hunan Provincial Department of Education [22A0318]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

The pathogenesis of Ureaplasma urealyticum infection is linked to the host inflammatory response; however, the specific molecular mechanisms underlying this phenomenon have not been fully elucidated. GrpE is a chaperonin that accelerates ADP release and ATP binding to DnaK, thereby enhancing the chaperone function of the HSP70 system under stress. However, alternative activities such as pro-inflammatory responses remain poorly understood. In this study, we report that the U. urealyticum GrpE exerts as a cytokine-inducing virulence factor toward macrophages. Using gene-knockout mice and specifi...

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Ureaplasma urealyticum GrpE protein elicits glycolysis-mediated inflammatory responses through TLR2 in macrophages

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