Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome

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成果类型：

期刊论文

作者：

Li, Tao;Liu, Youtan;Xu, Wei;Dai, Xingui;Liu, Ruimeng;...

通讯作者：

Chen, Zhongqing;Li, Yunfeng

作者机构：

[Li, Tao; Chen, Zhongqing; Xu, Wei] Southern Med Univ, Sch Clin Med 1, Nanfang Hosp, Dept Crit Care Med, Guangzhou 510515, Guangdong, Peoples R China.

[Li, Tao; Li, Yunfeng; Dai, Xingui] Univ South China, Peoples Hosp Chenzhou 1, Dept Crit Care Med, Inst Translat Med, Chenzhou 423000, Peoples R China.

[Liu, Youtan; Liu, Ruimeng] Southern Med Univ, Shenzhen Hosp, Dept Anesthesiol, Shenzhen 518110, Peoples R China.

[Gao, Youguang] Fujian Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Sch Clin Med 1, Fuzhou 350005, Fujian, Peoples R China.

通讯机构：

[Chen, Zhongqing] S

[Li, Yunfeng] U

Southern Med Univ, Sch Clin Med 1, Nanfang Hosp, Dept Crit Care Med, Guangzhou 510515, Guangdong, Peoples R China.

Univ South China, Peoples Hosp Chenzhou 1, Dept Crit Care Med, Inst Translat Med, Chenzhou 423000, Peoples R China.

语种：

英文

期刊：

Laboratory Investigation

ISSN：

0023-6837

年：

2019

卷：

期：

页码：

819-829

DOI：

10.1038/s41374-019-0191-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500066, 81670075, 81601708]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ6004, 2018JJ3015]; Joint Funds for the innovation of science and Technology of Fujian province [2016Y9012]; Natural Science Foundation of Fujian ProvinceNatural Science Foundation of Fujian Province [2016J01451]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313561]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Mitophagy removes dysfunctional mitochondria and is known to play an important role in the pathogenesis of several diseases; however, the role of mitophagy in acute respiratory distress syndrome (ARDS) remains poorly understood. While we have previously demonstrated that polydatin (PD) improves lipopolysaccharide (LPS)-induced ARDS, the specific mechanism remains unclear. In present study, we aimed to determine whether PD activates Parkin-dependent mitophagy to protect against LPS-induced mitochondria-dependent apoptosis and lung injury. To establish the ARDS model, C57BL/6 mice were intratrac...

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Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome

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