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Farnesoid X receptor: An important factor in blood glucose regulation.

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成果类型:
期刊论文
作者:
Hou, Yangfeng;Fan, Wenjing;Yang, Wenling;Samdani, Abdul Qadir;Jackson, Ampadu Okyere;...
通讯作者:
Qu, Shunlin
作者机构:
[Hou, Yangfeng; Yang, Wenling] Univ South China, Clin Med Dept, Hengyang Med Sch, Hengyang City 421001, Hunan, Peoples R China.
[Fan, Wenjing; Qu, Shunlin] Univ South China, Dept Pathophysiol, 28 West Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
[Fan, Wenjing] Univ South China, Affiliated Hosp 2, Emergency Dept, Hengyang City 421001, Hunan, Peoples R China.
[Samdani, Abdul Qadir] Univ South China, Affiliated Hosp 1, Spinal Surg Dept, Hengyang City 421001, Hunan, Peoples R China.
[Jackson, Ampadu Okyere] Univ South China, Hengyang Med Sch, Int Coll, Hengyang City 421001, Hunan, Peoples R China.
通讯机构:
[Qu, Shunlin] U
Univ South China, Dept Pathophysiol, 28 West Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Blood glucose;Farnesoid X receptor;Glycometabolism
期刊:
Clinica Chimica Acta
ISSN:
0009-8981
年:
2019
卷:
495
页码:
29-34
基金类别:
We thank our colleagues in Professor Qu's group for technical assistance and stimulating discussions during the review. The authors declare that they have no competing interests. All the authors agree. This work was supported by grants from the National Natural Science Foundation of China (81670424), the Key Scientific Research Fund of Hunan Provincial Education Department (15A166), the Scientific Research Fund of Hunan Provincial Health and Family Planning Commission (B2016087); the National Natural Science Foundation of Hunan Province (2015JJ2118, 2019JJ40258 and 2019JJ50502); the Aid Programme for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (2008-244); the Construct Programme of the Key Discipline in Hunan Province (2011-76); the Postgraduate Innovation Project of Scientific Research of University of South China (2015XCX38) and the project of “Research Study and Innovative Experiment Program for College Students” in University of South China (2017XJXZ031, 2017XJYZ048 and 2018XJXZ375).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid metabolism is mediated by FXR and closely related to the regulation of blood glucose (BG). FXR can regulate BG through multiple pathways. This review summarises recent studies on FXR regulation of BG balance via bile acid regulation, lowering glucagon-like peptide-1 (GLP-1), inhibiting gluconeogenesis, increasing insulin secretion and enhancing insulin sensitivity. In addition, the current review ...

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