期刊论文

Effect of parathyroid hormone on osteoporosis after spinal cord injury in rats and its mechanism

中文

中国药理学通报

1001-1978

2022

38

1

98-104

10.3969/j.issn.1001-1978.2022.01.019

湖南省卫生健康委员会2019年度科研计划课题项目（No C2019101）；

本校为第一机构

目的探究甲状旁腺激素(parathyroid hormone,PTH)对脊髓损伤(spinal cord injury,SCI)后大鼠骨质疏松的影响及其作用机制。方法SD大鼠随机性分为假手术组(Sham)、SCI模型组(SCI)、SCI +甲状旁腺激素组(SCI + PTH)、SCI + PTH +转染miR-146a无关片段组(SCI + PTH + NC)以及SCI + PTH +转染miR-146抑制剂组(SCI + PTH + miR-146a inhibitor组)。分别每3 d一次尾静脉注射给予大鼠60 μg·kg~(-1) PTH(SCI + PTH组)、60 μg·kg~(-1) PTH和20 pm miR-146a NC(SCI + PTH + NC组)或60 μg·kg~(-1) PTH和20 pm miR-146a inhibitor (SCI + PTH + miR-146a inhibitor组),连续8周。Sham组和SCI组大鼠同法...

Aim To explore the effect of parathyroid hormone on osteoporosis in rats after spinal cord injury(SCI)and its mechanism.Methods SD rats were divided into sham operation group(Sham), SCI model group(SCI), SCI+parathyroid hormone group(SCI+PTH)and SCI+PTH+transfected miR-146a irrelevant fragment group(SCI+PTH+NC)and SCI+PTH+transfection miR-146a inhibitor group(SCI+PTH+miR-146a inhibtor), and then given 60 μg·kg-1PTH(SCI+PTH group), 60 μg·kg-1PTH and 20 pm miR-146a NC(SCI+PTH+NC group)or 60 μg·kg-1PTH and 20 pm miR-146a inhibitor(SCI+PTH+mi...