期刊论文

Neu-P11 reduces IOP through inhibiting oxidative stress level of acute high IOP rats

中文

中国药理学通报

1001-1978

2017

33

5

637-641

10.3969/j.issn.1001-1978.2017.05.010

湖南省自然科学基金资助项目（No14JJ2084） 湖南省教育厅基金项目（No15C1203） 湖南省卫生计生委基金（No C201519） 南华大学‘蒸湘学者计划’资助（Xiangyang Tang）

本校为第一机构

目的褪黑素(melatonin, Mel)是由松果体分泌的一类吲哚类神经内分泌激素,具有调节昼夜节律和抗氧化等广泛的生物学作用。新型褪黑素非选择性受体激动剂Neu-P11与褪黑素作用相似。该文旨在研究Neu-P11对急性高眼压大鼠眼内压的影响及其相关机制。方法采用Trendelenburg卧位(头低脚高80°位置)法将30只健康8周龄SD大鼠建立急性高眼压模型,即动物被置于Trendelenburg卧位,用Tonopen XL接触眼压计每5 min测量1次眼内压,取20 min最大值。建模后将大鼠随机分为5组:正常眼压+生理盐水组、高眼压+生理盐水组、高眼压+10 mg·kg~(-1) Mel组、高眼压+20 mg·kg~(-1) Neu-P11组、高眼压+50 mg·kg~(-1) Neu...

Aim To explore the effect of Neu-P11, a novel melatonin agonist with similar function of melatonin, on IOP of acute high IOP animals and the related mechanism. Methods The experiment used the Trendelenburg position (head low feet high position of 80°) to establish acute high IOP model. Rats were placed in the Trendelenburg position and used Tonopen XL contact tonometer to measure IOP (every 5 minutes measured once IOP, and the maximum value in 20 minutes) in 8: 00 ∼9: 00 am. And then, thirty Sprague-Dawley rats (8 week-old) were divided into ...