期刊论文

中文

中国药理学通报

1001-1978

2015

31

6

827-833

10.3969/j.issn.1001-1978.2015.06.018

国家自然科学基金资助项目（No 81202535） 郴州市科技局资助项目（No CZ2014015）

本校为第一机构

目的探讨mmLDL对小鼠肠系膜动脉α_1受体的作用。方法小鼠尾静脉注射mmLDL,微血管肌张力描记仪观察NA引起的小鼠肠系膜动脉收缩量效曲线变化,RT-PCR、Western blot检测α_1受体及α_2受体表达。结果mmLDL引起NA收缩量效曲线明显增强,表现为E_(max)值由生理盐水(NS)组的(120.75±3.44)%上升为(161.00±6.87)%(P

Aim To investigate the effects of mmLDL on the up-regulation ofα1 receptors in moues mesenter- ic arteries. Methods Mice tail intravenous injection of mmLDL was used . Vitro sensitive myograph was empl- oyed to examine Noradrenaline ( NA) induced vascular contraction on mice mesenteric artery, and the mRNA and protein expressions ofα1 andα2 receptors were an-alyzed by real-time PCR and Western blot, respective-ly. Results mmLDL significantly increased NA in-duced concentration-contractile curve, and the data of Emax and pEC50 were from ( 122...