期刊论文

Zhao, L.-Y.

中文

中国药理学通报

1001-1978

2012

28

4

567-572

10.3969/j.issn.1001-1978.2012.04.029

湖南省高校创新平台开放基金项目资助（No 11K056） 湖南省“十二五”重点学科建设项目

本校为第一且通讯机构

目的探讨染料木素(genistein,Gen)对大鼠食饵性高脂血症对氧磷酶(paraoxonase,PON1)活性及C-反应蛋白(C-reactive protein,CRP)的影响。方法健康SD大鼠40只,♀♂各半,随机分为以下5组:①普食组;②高脂血症模型组;③低剂量Gen(0.5 mg·kg~(-1)·d~(-1))组;④高剂量Gen(5 mg·kg~(-1)·d~(-1))组;⑤辛伐他汀(5 mg·kg~(-1)·d~(-1))阳性药物对照组;除普食组给以普通饲料喂养外,其他组均饲以高脂饲料喂养加敌百虫(10 mg·kg~(-1)·d~(-1))腹腔注射,建立食饵性高脂血症模型。各组大鼠连续喂养及同时用药8周,每2周测1次体重,根据体重调整用药量;定期取血检测胆碱酯酶(acetylcholine esterase,AChE)、...

Aim: To investigate the effect of genistein on paraoxonase (PON1) activity and inflammatory factor C-reactive protein(CRP) of the hyperlipidemic rats induced by high-lipid food. Methods: Healthy Sprague-Dawley rats, twenty male and twenty female, were randomly divided into five groups: control group, hyperlipidemic model group, low-dose genisein (0.5 mg·kg -1 per day) group, high-dose genisein (5 mg·kg -1 per day) group and simvastatin group. All groups were fed with high fat food and intraperitoneally injected trichlorfon(10 mg·kg -1·day -...