期刊论文

Changes in expressions of Apelin-APJ receptor during the growth and aging of rat myocardium

Feng, F.

中文

中国药理学通报

Chinese Pharmacological Bulletin

1001-1978

2008

24

3

299-302

10.3321/j.issn:1001-1978.2008.03.005

国家自然科学基金资助项目（No 30371645） 湖南省教育厅优秀青年基金资助项目（No 038036）

本校为第一且通讯机构

目的apelin是新发现的内源性肽，其受体是G蛋白偶联受体APJ，该实验比较不同年龄大鼠心肌APJ受体及信号分子caveolin-1／ERK1／2的表达差异。方法 采用Western blot方法观察胎鼠、乳鼠、成年鼠、老龄鼠等不同年龄阶段心肌组织APJ受体、ERK1／2、pERK1／2、caveolin-1的表达及其增龄性变化。结果 随年龄增长APJ受体、caveolin-1表达增加，ERK1／2及pERK1／2随年龄增长表达减少。结论APJ受体及其caveolin-1／ERK1／2途径可能与心脏的生长发育、衰老过程有关。

Aim: To investigate the regulatory route and the role of APJ receptor in the growth and aging process of rat myocardium. Methods: Western blot was used to observe the changes of APJ receptor, ERK, pERK and caveolin-1 expression. Results: The findings showed that APJ receptor and caveolin-1 expression increased with age growth, but decreased slightly at the gerontism. The ERK and pERK expression decreased with age growth. Conclusion: Apelin-APJ receptor-caveolin-1/ERK1/2 route m...