期刊论文

Qin, X.-P.

中文

中国药理学通报

1001-1978

2004

20

10

1107-1111

10.3321/j.issn:1001-1978.2004.10.007

国家重点基础研究“973”资助项目 （G 2 0 0 0 0 5 690 5 ）； 国家自然基金资助项目 （ 3 0 0 70 870 ）；

本校为第一且通讯机构

目的比较氯沙坦和培哚普利逆转肾血管性高血压大鼠心血管重构作用及其机制,为临床用药提供实验依据.方法以经典两肾一夹肾血管性高血压大鼠为研究模型.采用鼠尾测压法测定大鼠血压的变化;反射免疫分析法测定大鼠血浆血管紧张素Ⅱ含量和肾素活性;称量法计算各组大鼠心脏与体重的比值;高清晰度数码照相扫描分析技术测定各组大鼠主动脉、肠系膜动脉血管管壁厚度、管壁厚度和管腔内径比值、管壁面积和管腔面积比值来估计两类药物对心血管重构的影响.结果高血压大鼠心脏与体重的比值、主动脉、肠系膜动脉血管管壁厚度和管腔内径比值、管壁面积和管腔面积比值与正常大鼠相比明显增大(P

Aim To compare the effects and mechanism of losartan and perindopril on the regression of cardiovascular remodeling in renovascular hypertensive rats. Methods The 2-kindey, 1-clip hypertensive rats (2K1C, Goldblatt) were prepared with Sprague-Dawley rat, weighing 200-250 g. Systolic blood pressure (SBP) was measured before/after operation and administration, using the tail-cuff method. The plasma concentration of angiotensin II or renin activity was determined by radioimmunoassay. The ratio of heart weight and body weight was calculated. The de...