Objective To explore the effect of excessive fluorosis on children's intelligence development in Chinese endemic fluorosis areas, Methods 5 independent investigations were selected by the strict criteria for meta - analysis, and the random effect model was applied for processing data. Results By comparing the high fluoride group with the control group, the average of effect scale was - 0. 286, 95% CI was ( - 0. 556, - 0. 016). Conclusion The meta - analysis suggests that the high fluoride concentration can cause the ...