OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zeng Zhaolin;Chen Jiaojiao;Wu Peng;Liu Yami;Zhang Tingting;...

通讯作者：

Wang Zuo

作者机构：

[Wang Zuo; Wei Dangheng; Zeng Zhaolin; Liu Yami; Tao Jun; Chen Jiaojiao; Wu Peng; Jiang Zhisheng] Univ South China, Inst Cardiovas Dis, Key Lab Atherosclerol Hunan Prov, Hengyang, Peoples R China.

[Wang Zuo; Wu Shiyuan; Wei Dangheng; Wu Peng; Xiao Jinyan] Univ South China, Cooperat Innovat Base, YueYang Maternal Child Med Hlth Hosp, Hengyang, Hunan, Peoples R China.

[Zhang Tingting] Sichuan Univ, West China Sch Med, School Rehabil Sci, Chengdu, Sichuan, Peoples R China.

[Wang Zuo] Univ South China, Cooperat Innovat Base, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wang Zuo] U

Univ South China, Cooperat Innovat Base, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

beta actin;cryopyrin;immunoglobulin enhancer binding protein;inflammasome;interleukin 18;interleukin 1beta;interleukin 1beta converting enzyme;microRNA;microRNA 125a;oxidized low density lipoprotein;procaspase 1;protein;reactive oxygen metabolite;tet2 protein;unclassified drug;cytokine;DNA binding protein;inflammasome;low density lipoprotein;microRNA;MIRN125 microRNA, human;oncoprotein;oxidized low density lipoprotein;TET2 protein, human;Article;atherosclerosis;controlled study;cytokine release;DNA methylation;enzyme linked immunosorbent assay;human;human cell;HUVEC cell line;mitochondrial membrane potential;priority journal;protein expression;pyroptosis;real time polymerase chain reaction;signal transduction;vascular endothelial cell;Western blotting;apoptosis;cell culture;endothelium cell;metabolism;mitochondrion;physiology;pyroptosis;Apoptosis;Atherosclerosis;Cells, Cultured;Cytokines;DNA Methylation;DNA-Binding Proteins;Endothelial Cells;Humans;Inflammasomes;Lipoproteins, LDL;MicroRNAs;Mitochondria;Proto-Oncogene Proteins;Pyroptosis;Reactive Oxygen Species

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2019

卷：

234

期：

页码：

7475-7491

DOI：

10.1002/jcp.27509

基金类别：

This study was supported by the National Natural Science Foundation of China (No. 81070221) and the Project of Hunan Provincial Health and Family Planning Commission (B2016139, B2016133); Project of Hunan Provincial Department of Education (16C1392). Project of Hunan Provincial Health and Family Planning Commission, Grant/Award Numbers: B2016133, B2016139; Project of Hunan Provincial Department of Education, Grant/ Award Number: 16C1392; National Natural Science Foundation of China, Grant/Award Number: No. 81070221; Natural Science Foundation of China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Pyroptosis participates in the formation and development of atherosclerosis (As) by promoting inflammatory factor release and is closely related to the stability of atherosclerotic plaque. MicroRNAs can regulate the expression of target genes at the posttranscriptional level. Previous studies have shown that miR-125a-5p increases in hyperlipidemic–hyperglycemic conditions and is involved in apoptosis, but its specific role in pyroptosis and As remains unclear. We propose that miR-125a-5p may be implicated in oxidized low-density lipoprotein (o...

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OxLDL induces vascular endothelial cell pyroptosis through miR-125a-5p/TET2 pathway

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