Elevated LAG-3 on CD4+ T cells negatively correlates with neutralizing antibody response during HCV infection

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成果类型：

期刊论文

作者：

Zhang, Jian;Liu, Wenpei;Xie, Ting;Huang, Liyan;Hu, Yabin;...

通讯作者：

Qu, Xiaowang

作者机构：

[Xie, Ting; Tang, Ping; Zhang, Jian; Qu, Xiaowang; Niu, Ling; Liu, Ziyan; Guo, Fengfan; Huang, Liyan; Hu, Yabin; Jin, Kun; Wen, Bo; Liu, Wenpei; Zhang, Ping] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Chenzhou 423000, Hunan, Peoples R China.

[Qu, Xiaowang; Liu, Wenpei] Southern Med Univ, Affiliated Peoples Hosp Chenzhou 1, Chenzhou 423000, Hunan, Peoples R China.

[Qu, Xiaowang] 102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

通讯机构：

[Qu, Xiaowang] 1

102 Luojiajing, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

*Follicular helper T cell;*Hepatitis C virus;*Lymphocyte activation gene-3;*Neutralizing antibody;*Regulatory T cell

期刊：

Immunology Letters

ISSN：

0165-2478

年：

2019

卷：

212

页码：

46-52

DOI：

10.1016/j.imlet.2019.06.003

基金类别：

This study was supported in part by the Natural Science Foundation of China (grant numbers 81471959 and 81501746 ) and Clinical Medical Innovation Technology Guide Project of Hunan Province (grant number: 2018SK5030 , 2018SK50304 and 2018SK50308 ) and the Science Foundation of The First People’s Hospital of Chenzhou (grant number N2018-001 ).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Lymphocyte activation gene-3 (LAG-3), an inhibitory molecule, which has been shown co-expressed with multiple inhibitory receptors on CD8+ T and natural killer (NK) cells and negatively regulates T and NK cell responses during hepatitis C virus (HCV) infection. However, whether LAG-3 is involved in the regulation of the antibody response remains unclear. This study aims to investigate the relationship of LAG-3 with neutralizing antibody (nAb) response during HCV infection. A total of 66 HCV-infected individuals and 36 sex- and age-matched healt...

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Elevated LAG-3 on CD4+ T cells negatively correlates with neutralizing antibody response during HCV infection

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