3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey

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成果类型：

期刊论文

作者：

Wang, Xiaomei;Wu, Suqiang;Guan, Jingwen;Chen, Lanhua;Sho, Cen;...

通讯作者：

Wang, Jianqiang;Juan Diwu;Wang, Shuao

作者机构：

[Wang, Jianqiang; Wang, Xiaomei] Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Shanghai 201800, Peoples R China.

[Wang, Jianqiang; Wang, Xiaomei] Univ Chinese Acad Sci, Beijing 210049, Peoples R China.

[Sho, Cen; Juan Diwu; Wang, Shuao; Chen, Lanhua; Wang, Xiaomei; Guan, Jingwen; Wan, Jianmei] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China.

[Sho, Cen; Juan Diwu; Wang, Shuao; Chen, Lanhua; Wang, Xiaomei; Guan, Jingwen; Wan, Jianmei] Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China.

[Wu, Suqiang; Liu, Yong] Univ South China, Acad Environm Protect & Safety Engn, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Jianqiang] C

[Wang, Jianqiang] U

[Juan, DW; Wang, SA] S

Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Shanghai 201800, Peoples R China.

Univ Chinese Acad Sci, Beijing 210049, Peoples R China.

语种：

英文

期刊：

INORGANIC CHEMISTRY

ISSN：

0020-1669

年：

2019

卷：

期：

页码：

3349-3354

DOI：

10.1021/acs.inorgchem.8b03442

基金类别：

We thank the National Natural Science Foundation of China (21771133, U1532259, 21422704, and 21790370), the “Strategic Priority Research Program” of the Chinese Academy of Sciences, Grant XDA02040600, the “Young Thousand Talents Program” in China, and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) for providing financial support for this work.

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摘要：

Uranium poses a threat for severe renal and bone damage in vivo. With the rapid development of nuclear industry, it is more urgent than ever to search for potential in vivo uranium chelators. In this work, 3-hydroxy-2-pyrrolidinone (HPD) is investigated as a new potential uranium decorporation ligand. The potentiometric titration measurements were carried out, and the stability constants were determined to be log β 110 = 10.5(7), log β 120 = 20.7(9), and log β 130 = 28.2(4). The species distribution diagram shows that nearly all uranyl is co...

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3-Hydroxy-2-Pyrrolidinone as a Potential Bidentate Ligand for in Vivo Chelation of Uranyl with Low Cytotoxicity and Moderate Decorporation Efficacy: A Solution Thermodynamics, Structural Chemistry, and in Vivo Uranyl Removal Survey

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