期刊论文

Tang, Zhi-Bin

英文

Clinica Chimica Acta

0009-8981

2014

431

33-39

10.1016/j.cca.2014.01.012

It is well established that the formation of macrophage foam cells resulting from cholesterol accumulation in the arterial intima is a major hallmark of early stage of atherosclerotic lesions. A variety of molecules have been shown to be implicated in maintaining a balance between influx and efflux of lipids from macrophages. This balance depends on reduced cholesterol influx through scavenger receptors such as CD36, and increased efflux through reverse cholesterol transport (RCT), a

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Interleukin-17 (IL-17) A, the most important cytokine of the IL-17 family predominantly secreted by T helper 17 (Th17) cells, plays a critical role in the development of inflammatory diseases. Its receptor is an obligate heterodimer composed of IL-17 receptor (IL-17R) A and C, the main members of the IL-17R family. Binding of IL-17A to the IL-17RA/C complex can activate a variety of downstream signaling pathways such as nuclear factor kappa-B (NF-κB), activator protein 1 (AP1) and CCAAT/enhancer-binding protein (C/EBP) to induce the expression...