Nonpathogenic colonization with Chlamydia in the gastrointestinal tract as oral vaccination for inducing transmucosal protection

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Luying;Zhu, Cuiming;Zhang, Tianyuan;Tian, Qi;Zhang, Nu;...

通讯作者：

Xue, Min;Zhong, Guangming

作者机构：

[Xue, Min; Wang, Luying] Cent S Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.

[Tian, Qi; Zhu, Cuiming; Wang, Luying; Zhang, Tianyuan; Zhang, Nu; Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA.

[Zhu, Cuiming] Univ South China, Dept Microbiol, Hengyang, Hunan, Peoples R China.

[Morrison, Sandra; Morrison, Richard] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA.

通讯机构：

[Xue, Min] C

[Zhong, Guangming] U

Cent S Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.

Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA.

语种：

英文

关键词：

Chlamydia muridarum;oral inoculation;transmucosal immunity;nonpathogenic;Chlamydia;gastrointestinal infection;mucosal immunity;oral vaccines

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2018

卷：

期：

DOI：

10.1128/IAI.00630-17

基金类别：

U.S. NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01AI121989]; Central South University 3rd Xiangya Hospital Endowment Fund; China Scholarship CouncilChina Scholarship Council; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21AI105712, R01AI121989, R01AI121989, R01AI121989] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia has been detected in the gastrointestinal tracts of humans and animals. We now report that gastrointestinal Chlamydia muridarum is able to induce robust transmucosal protection in mice. C. muridarum colonization in the gastrointestinal tract correlated with both a shortened course of C. muridarum genital tract infection and stronger protection against subsequent genital tract challenge infection. Mice preinoculated intragastrically with C. muridarum became highly resistant to subsequent C. muridarum infection in the genital tract, res...

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Nonpathogenic colonization with Chlamydia in the gastrointestinal tract as oral vaccination for inducing transmucosal protection

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