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Expression of LMP and EBNA genes in Epstein-Barr virus-associated lymphomas in Hu-PBL/SCID mice

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成果类型:
期刊论文
作者:
Tang, Yunlian;Lu, Suli;Gan, Xiaoning;Liu, Fang;Zhang, Yang;...
通讯作者:
Hong, Li
作者机构:
[Zhang, Yang; Tang, Yunlian; Hong, Li; Lu, Suli; Liu, Fang; Pan, Yuxia; Gan, Ruliang; Gan, Xiaoning; Luo, Chunyan] Univ South China, Coll Med, Canc Res Inst, 28 Chang Sheng Xi Ave, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Yang; Tang, Yunlian; Liu, Fang; Gan, Ruliang] Univ South China, Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.
[Lu, Suli] Hunan Polytech Environm & Biol, Dept Anat, Hengyang 421001, Hunan, Peoples R China.
[Luo, Chunyan] Hunan Polytech Environm & Biol, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.
[Hong, Li] Univ South China, Coll Med, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Hong, Li] U
Univ South China, Coll Med, Canc Res Inst, 28 Chang Sheng Xi Ave, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Epstein-Barr virus;induced lymphoma;viral gene expression;latent membrane protein;EBV nuclear antigen;SCID mouse
期刊:
ONCOLOGY REPORTS
ISSN:
1021-335X
年:
2016
卷:
35
期:
2
页码:
905-911
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272182, 81372134]; Construct Program of the Key Discipline in Hunan Province [2011-76]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2014-405]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Transplantation of peripheral blood lymphocytes (PBLs) from healthy humans with latent Epstein-Barr virus (EBV) infection into severe combined immunodeficiency (SCID) mice results in development of EBV-associated human B-cell lymphoma. However, the expression of EBV genes in relation to lymphoma development has not been reported. We investigated latent membrane protein (LMP) and EBV nuclear antigen (EBNA) gene expression in PBLs from EBV-positive blood donors and induced-lymphoma cells from SCID mice to elucidate the functions and effects of the EBV genome in the occurrence and development of ...

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