Aspirin Increases Apolipoprotein-A-I-Mediated Cholesterol Efflux via Enhancing Expression of ATP-Binding Cassette Transporter A1

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成果类型：

期刊论文

作者：

Wang, Yu-Hua;Chen, Yan-Fang;Chen, Shao-Rui;Chen, Xi;Chen, Jian-Wien;...

通讯作者：

Liu, Pei-Qing

作者机构：

[Wang, Yu-Hua] Nanhua Univ, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Liu, Pei-Qing] Sun Yat Sen Univ, Guangzhou Higher Educ Mega Ctr, Lab Pharmacol & Toxicol, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China.

[Mou, Yong-gao] Sun Yat Sen Univ, Dept Neurosurg, Ctr Canc, Guangzhou 510275, Guangdong, Peoples R China.

[Liu, Pei-Qing] Sun Yat Sen Univ, Guangzhou Higher Educ Mega Ctr, Lab Pharmacol & Toxicol, Sch Pharmaceut Sci, Wai Huan Dong Rd 132, Guangzhou 510275, Guangdong, Peoples R China.

通讯机构：

[Liu, Pei-Qing] S

Sun Yat Sen Univ, Guangzhou Higher Educ Mega Ctr, Lab Pharmacol & Toxicol, Sch Pharmaceut Sci, Wai Huan Dong Rd 132, Guangzhou 510275, Guangdong, Peoples R China.

语种：

英文

关键词：

Aspirin;ATP-binding cassette transporter A1;Cholesterol efflux;Atherosclerosis;Peroxisome proliferator-activated receptor-alpha

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2010

卷：

期：

5-6

页码：

320-326

DOI：

10.1159/000321727

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30811120434, 30772576]; National Science and Technology Major Project of China 'Key New Drug Creation and Manufacturing Program' [2009ZX09102-152, 2009ZX09303-007]; Major Program in Key Fields of the People's Government of Guangdong Province [2003A30904]; Key Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [7117380]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Background: The efflux of cellular cholesterol mediated by apolipoprotein (apo)A-I and ATP-binding cassette transporter A1 (ABCA1) is a major pathway of reverse cholesterol transport. We investigated the effect of aspirin on this process. Methods: The expression levels of ABCA1 in RAW264.7 cells were determined using reverse transcription polymerase chain reaction and Western blot analysis. H-3-cholesterol efflux was measured by scintillation counting. Results: 0.5 mmol/laspirin increased apoA-I-mediated cholesterol efflux and increased the expression of ABCA1. By increasing the dose of aspiri...

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Aspirin Increases Apolipoprotein-A-I-Mediated Cholesterol Efflux via Enhancing Expression of ATP-Binding Cassette Transporter A1

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