Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway

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成果类型：

期刊论文

作者：

Shuchen Liu;Xiaoxia Zhu;Zhuona Wu;Runtian Li;Zhiyun Meng;...

通讯作者：

Guifang Dou

作者机构：

[Shuchen Liu; Xiaoxia Zhu; Zhuona Wu; Runtian Li; Zhiyun Meng; Ruolan Gu; Hui Gan] Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China

[Lintao Li] School of Public Health, University of South China, Hengyang 421001, China

Author to whom correspondence should be addressed.

[Haiyang Wu] Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China<&wdkj&>School of Public Health, University of South China, Hengyang 421001, China

[Guifang Dou] Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China<&wdkj&>Author to whom correspondence should be addressed.

通讯机构：

[Guifang Dou] B

Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

radiation-induced intestinal injury;tea polyphenol;ferroptosis;HSP90;gut microbiota;metabolites

期刊：

Antioxidants

ISSN：

2076-3921

年：

2025

卷：

期：

页码：

580-

DOI：

10.3390/antiox14050580

基金类别：

This work was supported by grants from the Beijing Science and Technology Program (No.1916315ZD00900104).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Radiation-induced intestinal injury (RIII) is a significant concern for cancer patients receiving radiation therapy, as it can lead to complications such as radiation enteropathy. Presently, there are limited options for preventing or treating RIII. Tea polyphenols (TP), found in tea, provide various health benefits, but their antiradiation mechanisms are not fully understood. C57BL/6 mice pre-treated with TP for five days showed a significant improvement in survival rates after being exposed to 10 Gy of 60Co radiation. In the same way, abdominal exposure to 15 Gy of 60Co radiation effectively...

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Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway

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