Sun Yat Sen Univ, Inst Canc, Ctr Canc, Guangzhou 510060, Peoples R China.
Nanhua Univ, Inst Pharmacol, Hengyang 421001, Peoples R China.
[Zhou, JM] Sun Yat Sen Univ, Inst Canc, Ctr Canc, 651 DongFeng Rd E, Guangzhou 510060, Peoples R China.
通讯机构：
[Zhou, JM] S
Sun Yat Sen Univ, Inst Canc, Ctr Canc, 651 DongFeng Rd E, Guangzhou 510060, Peoples R China.
语种：
英文
关键词：
hepatocellular carcinoma;manumycin;apoptosis
期刊：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN：
1107-3756
年：
2003
卷：
12
期：
6
页码：
955-959
机构署名：
本校为其他机构
院系归属：
药学与生物科学学院
摘要：
Farnesyltransferase inhibitors (FTIs) were developed to prevent Ras processing and thus to be effective agents for the treatment of cancers harbouring mutated ras. In the present study, HepG2 cells underwent internucleosomal DNA fragmentation after treatment with farnesyltransferase inhibitor manumycin (20 muM) for 12 h. Flow cytometric analysis showed that HepG2 cells were accumulated in the G(2)/M phase of the cell cycle and the number of apoptotic sub-G1 fraction of cells was increased after treatment with manumycin in a time-dependent manner. During the induction of apoptosis, expression o...
